Dr Matilde Leonardi discusses the goals and outcomes of the 3-year EU-funded PATHWAYS project, designed to help people with chronic diseases to enter or remain active in the workforce. Dr Leonardi, neurologist and paediatrician, chaired the project and holds numerous positions including Director of the Coma Research Center and of the Italian WHO-Collaborating Centre Research Branch at National Neurological Institute Carlo Besta and Adjunct Professor of Neurology, Disability and Public Health at Catholic University.